里番色列全彩h工口人妻_精品人妻AV一区二区三区_bbw女厕bbw撒尿hd_日韩视频在线观看

首頁(yè) >> 產(chǎn)品展示 >> 抗體 >> chromotek代理商 >> Chromotek/F2H®-Kit Androgen Receptor

Chromotek/F2H®-Kit Androgen Receptor

簡(jiǎn)要描述:Chromotek/F2H®-Kit Androgen Receptor Analyze modulators of the human Androgen Receptor
  Detect early steps of Androgen Receptor activation

  • 產(chǎn)品型號(hào):
  • 廠商性質(zhì):經(jīng)銷(xiāo)商
  • 更新時(shí)間:2018-01-22
  • 訪  問(wèn)  量:1601
詳細(xì)資料

Chromotek/F2H®-Kit Androgen Receptor

 螞蟻淘介紹:

螞蟻淘,【正品極速】生物醫(yī)學(xué)科研用品輕松購(gòu)

螞蟻淘(ebiomall)是一家生命科學(xué)領(lǐng)域的垂直電商平臺(tái),公司專(zhuān)注生物醫(yī)學(xué)科研用品的  導(dǎo)購(gòu)和品牌推廣,為海外廠方與國(guó)內(nèi)代理經(jīng)銷(xiāo)商搭建跨境貿(mào)易系統(tǒng)和交流平臺(tái)。

    產(chǎn)品齊全,200+分類(lèi),1000+品牌,500萬(wàn)+產(chǎn)品信息。100%正品,專(zhuān)業(yè)售后,到貨快,在線下單, 簡(jiǎn)單輕松,節(jié)省科學(xué)家寶貴的科研時(shí)間。

借助互聯(lián)網(wǎng)平等而開(kāi)放的力量,矢志實(shí)現(xiàn)生命科學(xué)領(lǐng)域的信息同步,我們相信一群充滿夢(mèng)想的人,可以憑借著專(zhuān)業(yè)與執(zhí)著,讓你的購(gòu)物更輕松!

Chromotek/F2H®-Kit Androgen Receptor

  Analyze modulators of the human Androgen Receptor

  Detect early steps of Androgen Receptor activation

  Visualized in live mammalian cells

  Real-time agonists and antagonists screening

  Convenient readout using an epi-fluorescence microscope

  The human Androgen receptor (AR) is an important target for developing drug therapies combating prostate cancer. The very early event in AR activation, namely the intramolecular interaction between the N- and C-terminus of AR, can now be analyzed with the ChromoTek Fluorescent-Two Hybrid (F2H®) AR: wild-type (wt), as well as several mutant AR forms can be investigated.

Chromotek/F2H®-Kit Androgen Receptor  

Assay principle:

  AR is expressed as two separate domains: AR-LBD (ligand binding domain), comprising the AR’s C-terminus, either wt or mut, fused to GFP: AR-LBD-GFP

  AR-NTD (N-terminal domain), comprising the AR’s N-terminus, fused to RFP: AR-NTD-RFP

  F2H®-BHK cells express components of the protein-protein interaction platform, which recruits GFP-tagged AR-LBD to a specific location in the nucleus

  AR-LBD-GFP and AR-NTD-RFP constructs are co-transfected into the F2H®-BHK cells

  AR-LBD-GFP forms a bright green spot at the specific location in the nuclei whereas AR-NTD-RFP is diffusely distributed in the nucleus

  Upon stimulation by an agonist (e.g. DHT), immobilized AR-LBD-GFP undergoes a conformation change and recruits AR-NTD-RFP: AR-NTD-RFP forms a bright red spot superimposed with the green spot.

  Results:

  Green spot is present, red spot is absent => assay works: no interaction

  Green spot is present, red spot is present at the same location => assay works: interaction

  

 

  Figure: AR-LBD-GFP (top left) forms bright green spots at the genetic Platform in nuclei of F2H-BHK cells. Before addition of DHT, AR-NTD-RFP (bottom left) is dispersed in the nuclei. Upon 20 min incubation with 10nM DHT, the red spots appear (bottom right, arrows) at the location of the green spots, indicating induction of the interaction between AR-LBD and AR-NTD.

  Reversible Screening:

  The F2H AR assay is fully reversible: the AR wt interaction can be induced by an agonist (e.g. 0.25nM DHT) and then subsequently disrupted by addition of a potent antagonist (e.g. 10µM bicalutamide).

如果你對(duì)Chromotek/F2H®-Kit Androgen Receptor感興趣,想了解更詳細(xì)的產(chǎn)品信息,填寫(xiě)下表直接與廠家聯(lián)系:

留言框

  • 產(chǎn)品:

  • 您的單位:

  • 您的姓名:

  • 聯(lián)系電話:

  • 常用郵箱:

  • 省份:

  • 詳細(xì)地址:

  • 補(bǔ)充說(shuō)明:

  • 驗(yàn)證碼:

    請(qǐng)輸入計(jì)算結(jié)果(填寫(xiě)阿拉伯?dāng)?shù)字),如:三加四=7

蘇州螞蟻淘生物科技有限公司(chuandaishi.com)主營(yíng)產(chǎn)品:海外生命科學(xué)試劑儀器代購(gòu)

總訪問(wèn)量:256407  管理登陸  技術(shù)支持:化工儀器網(wǎng)  sitemap.xml

版權(quán)所有 © 2025 蘇州螞蟻淘生物科技有限公司  ICP備案號(hào):蘇ICP備17049038號(hào)-2
在線留言 聯(lián)系方式 二維碼

服務(wù)熱線

18915418616

掃一掃,關(guān)注我們

成人午夜精品一区二区三区| 国产成人愉拍精品久久| 亚洲欧美一区二区三区视频| 99精品久久久久久人妻精品| 91人妻一区二区三区蜜桃麻豆日韩| 丰满熟妇bbwbbwbbw| 国产伦精品一区二区三区免费下载| 久久久久国产精品嫩草影院| 欲求不满人妻与公中出伊藤舞雪 | 91香蕉视频免费在线观看| 久久久久久女人| 久久亚洲av午夜福利精品一区| GOGO人体艺术| 国产乱子伦一区二区三区| 欧美人妻一区二区三区四区五区| 欧美成人一区二区在线观看| 午夜福利小视频| 成人综合婷婷国产精品久久 | 欧美最猛黑人xxxx黑人猛叫黄| 久久精品久久久久久久久| 中文字幕一区二区三区成人av | 美女国产毛片a区内射| 精品人妻久久久| 亚洲高潮毛片无遮挡免费| 黑人巨大精品欧美黑寡妇| 亚洲国产精品女人| 俺来俺也去www色在线观看| 精品国产91久久久久久老师| 欧美日韩久久久久久| 91精品国产综合一区二区三区大| 国产欧美一区二区在线| y111111国产精品久久婷婷| 欧美成人一区二区在线观看| 国产美女无套在线播放| 欧美丰满熟妇bbbbb| 天天干天天天干| 91亚洲国产成人久久精品| 国产无线一线二线| 国产欧美又粗又猛又爽| 啊灬啊灬啊灬快灬深用两性| 国产精品黄色在线观看|